Cpds. of formula (I):- where R = H, halogen, lower alkyl or CF3, R1 = H, lower alkyl or lower alkenyl, R2-R5 = H or lower alkyl, n = 1, 2, 3 or 4 and non-toxic acid addition salts thereof. Anti-depressants comparing favourably with imipramine and amitriptyline in an anti-tetrabenzine depression test in mice. 6-Cl-2-carboxy-indole (26 pts.), Et2O (500 pts.) and SOCl2 (50 pts.) are stirred 8 hrs. at room temp., then Et2O and excess SOCl2 are evaporated off to leave crude 6-Cl-2-chlorocarbonyl-indole. 10.7 pts. of this crude material in Et2O (100 pts.) are added dropwise with stirring and cooling to N-(2-NH2-Et)-morpholine (13 pts.) in Et2O (100 pts.) and the mixture is left 20 hrs. at room temp., then mixed with 2 N NaOH (50 pts.). 6-Cl-N-(2-morpholinoethyl)-2-indole-carboxamide (11.6 pts.),.
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