首页> 外国专利> PROCESS FOR THE PREPARATION OF 2-(2-ARYLVINYL)-1,4,5,6-TETRAHYDROPYRIMIDINES AND 2-(2-ARYLVINYL)-2-IMIDAZOLINES AND INTERMEDIATES THEREFOR

PROCESS FOR THE PREPARATION OF 2-(2-ARYLVINYL)-1,4,5,6-TETRAHYDROPYRIMIDINES AND 2-(2-ARYLVINYL)-2-IMIDAZOLINES AND INTERMEDIATES THEREFOR

机译:制备2-(2-芳基乙烯基)-1,4,5,6-四氢嘧啶和2-(2-芳基乙烯基)-2-咪唑并制备中间体的方法

摘要

1,184,376. Anthelmintics. CHAS. PFIZER & CO. Inc. 14 July, 1967 [24 Feb., 1967], No. 32493/67. Heading A5B. [Also in Division C2] Helminthiasis in animals may be treated by the administration of a therapeutic dosage of a compound of the formula: or an acid addition salt thereof, wherein Y is wherein R 2 is hydrogen, methyl, ethyl, chloro, bromo or fluoro, R 3 is hydrogen or methyl, R 1 is hydrogen or methyl, R 5 is chloro, bromo, iodo, fluoro, hydrogen or methyl and n is 2 or 3 with the proviso that when n is 2 R 5 is methyl. The compounds may be administered orally (e.g. in an amount of 0.5-150 mg per kg. of body weight) or parenterally (e.g. in an amount of 5-150 mg per kg of body weight). For oral administration they may be formulated as tablets, capsules or liquid mixtures and solutions and for parenteral administration they may be used in a variety of vehicles which may be aqueous or non-aqueous.
机译:1,184,376。驱虫药。 CHAS。 PFIZER&CO。Inc. 1967年7月14日[1967年2月24日],第32493/67号。标题A5B。 [也在C2分部中]动物的蠕虫病可以通过施用治疗剂量的下式化合物或其酸加成盐来治疗:其中Y是其中R 2是氢,甲基,乙基,氯,溴或氟,R 3为氢或甲基,R 1为氢或甲基,R 5为氯,溴,碘,氟,氢或甲基,n为2或3,条件是当n为2时,R 5为甲基。化合物可以口服(例如每公斤体重0.5-150mg)或肠胃外(例如每公斤体重5-150mg)给药。对于口服给药,它们可以配制成片剂,胶囊剂或液体混合物和溶液剂,对于肠胃外给药,它们可以用于各种载体,它们可以是水性或非水性的。

著录项

  • 公开/公告号IL29452A

    专利类型

  • 公开/公告日1971-08-25

    原文格式PDF

  • 申请/专利权人 PFIZER INC;

    申请/专利号IL19680029452

  • 发明设计人

    申请日1968-02-11

  • 分类号C07D49/34;C07D51/28;C07D63/12;C07D99/02;

  • 国家 IL

  • 入库时间 2022-08-23 10:14:37

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