BENZIMIDAZO (2,1-B) QUINAZOLIN-12(6H)ONE IMMUNO SUPPRESSANTS AND NOVEL BENZIMIDAZO (2,1-B) QUINAZOLIN-12(6H)ONES

摘要

Benzimidazo [2,1-b]quinazolin- 12(6H)ones, immunosuppressives and agents for treatment of auto-immune diseases, are prepared via (1) reacting a 2-chlorobenzimidazole with an anthranilic acid or ester; (2) reacting a 2-aminobenzimidazole with an anthranilic acid or ester in the presence of trifluoroacetic acid or (3) reacting a 2-methylmercaptobenzimidazole with an anthraniloyl halide hydrohalide.