A procedure for the preparation of new 5-aroil-pirrol-2-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding)

摘要

A procedure for the preparation of new 5-aroyl-pyrrole-2-carboxylic acids and carboxylic acid derivatives of general formula: **(See formula)** and the therapeutically useful salts of the corresponding carboxylic acids, where Ar is a phenyl group or a phenyl group substituted with one or more of the halogen, lower alkyl, lower alkoxy, nitro, amino, methylthio and cyano radicals and R3 represents a member selected from the group consisting of COOH, COO-lower alkyl, CONH2, CONH-lower alkyl and CON- (lower alkyl) 2, whose process is characterized by reacting a carboxylic acid halide of general formula: **(See formula)** where Ar'has the meaning given above to Ar except for the aminophenyl group, with a pyrrole derivative of general formula: **(See formula)** in the presence of a Lewis acid and a solvent and, if desired, subjecting the ester thus obtained of the general formula **(See formula)** to one or both of the following operations, in arbitrary order: a) hydrolysis to free carboxylic acid and, if desired, subsequent conversion of said acid to the corresponding amide with ammonia or with an appropriate lower alkylamine or di (lower alkyl) amine or treating said acid with a base, in order to convert said acid in a therapeutically useful sa b) in the case that Ar'is a nitrophenyl group, catalytically hydrogenate said product to give the corresponding compound in which Ar is aminophenyl. (Machine-translation by Google Translate, not legally binding)