Sulphanilamide derivs - by catalytic hydrogenation of corresp alkenyl derivs-hypoglycaemic activity

摘要

New cpds. of formula (I): (where R1 = alkyl (3-5C) or cycloalkyl(5-7C); R2 = methyl or ethyl; or acid -addn. salts of (I) are prepd. by reduction of a cpd. (II): 1: - NH2 is - X and R1 is R1' where R1' = alkenyl (3-5C) or cycloalkenyl(5-7C); X = amino or a residue which can be hydrolyses, reduced etc. to a free amino group. reduction pref. using H2 in the presence of a catalyst (I) have hypoglycaemic activity, esp. 1-sulphanilyl-2-imino-3-butyl-5-ethyl-imidazolidine shows this activity upon peroral or parenteral administration and may be used in the treatment of diabetes.