Beta-phenylalkanoic acids esters and amides having - analgesic and anti-inflammatory activity

摘要

Beta-phenylalkanoic acids esters and amides having analgesic and anti-inflammatory activity. M3A. Are new compounds of formula (I): including the salts of the acids and optical isomers. (X = COOH, esterified or as an amide; A = OH, alkoxy, alkenyloxy, acyloxy; B = aliphatic hydrocarbyl, H; A with B may form a direct bond; B with R2 may form an alkylene chain; R' and R2 = H, aliphatic hydrocarbyl; Ph = phenylene; R = opt. substd. cycloaliphatic hydrocarbyl). Uses as analgesic and anti-inflammatory agents, also as intermediates for other drugs. Preferred cpds. are of formula: (R4 = 1-cycloalkenyl (C5-C7), opt. substd. by alkoxy, alkyl; R5 = H, alkyl; A' = OH; B' = H, alkyl; or A' + B' = direct bond; Rz = alkoxy (C1-C4), NH2, OH); esp. the cpd. Preparation by conventional methods; also by isomerisation with double-bond removal of novel intermediates of formula: (Ro = aliphatic hydrocarbylene), e.g. by use of strong alkalis or acids.