Thiol-type thiamine thionothiolcarbonates, i.e. O-(lower)-alkoxycarbonyl-S-(substituted or unsubstituted)-phenylthiothiocarbonylthiamines, being prepared from S-alkali salts of O-(lower)-alkoxycarbonylthiamines by an interaction with (substituted or unsubstituted)-phenylthiothiocarbonyl group-introducing agents, or from S-alkali salts of thiamine by an interaction with the (substituted or unsubstituted)-phenylthiothiocarbonyl group-introducing agents followed by alkoxycarbonylation of the O-position, possessing anti-inflammatory activity and also rapid, prolonged and high level vitamin B1 activity, and being sufficiently stable for various pharmaceutical preparations.
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