PROCESS FOR PREPARING 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE

摘要

The known 7-chloro-1,3-dihydro-l-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one which was found to be pharmacologically effective in neuro-psychic disorders is prepared easily and in high yield by an improved process comprising the reaction of a novel intermediate, N-aminoacetyl-5-chloro-N-methylanthranilic acid, with phosphorus pentachloride followed by reacting with benzene in the presence of aluminum chloride, the intermediate which is also found to have valuable pharmacological activities being, in turn, prepared by the reaction of 5-chloro-N-methyl-N-phthalimidoacetylanthranilic acid with hydrazine.