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Process for the preparation of aperfeicoado dense crystals of a new form polimorfica hydrochloride lincomycin
Process for the preparation of aperfeicoado dense crystals of a new form polimorfica hydrochloride lincomycin
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机译:新型波莫菲卡盐酸林可霉素的阿普非柯多致密晶体的制备方法
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摘要
Polymorph II of lincomycin hydrochloride has a higher density than the normal polymorph I, is more suitable for encapsulating and has a characteristic X-ray diffraction pattern. It is obtained by adding acetone slowly with stirring to an aqueous solution of lincomycin hydrochloride at a temperature above 25 DEG C. Lincomycin hydrochloride polymorph I is prepared in Specification 976,765. A therapeutic composition in the form of a capsule contains lincomycin hydrochloride polymorph II.
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