PROCESS FOR THE PREPARATION OF NEW COMPLEXES OF BIOLOGICALLY ACTIVE PEPTIDES, POLYPEPTIDES, PROTEINS OR DERIVATIVES OR SALTS THEREOF HAVING PROLONGED AND/OR INCREASED ACTIVITY

摘要

Complexes of biologically active natural or synthetic peptides, polypeptides, or proteins, or their salts or derivs. with inorganic silicon cpds. contg. Si-O bonds, pref. natural or synthetic silica, silicic acid, polysilicic acid or the salts thereof, are prepd. by mixing the components in aq. medium, e.g. an insulin soln. is mixed with an AlMg silicate ('Veegum' RTM). Biologically active cpds. envisaged include those with hormonal, antibiotic, antimycotic or cytostatic activity, e.g. hypertensin, vasopressin, Polymixin B, ACTH, HCG, etc.