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Alpha amino-benzyl penicillins - useful as oral antibiotics
Alpha amino-benzyl penicillins - useful as oral antibiotics
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机译:α-氨基苄青霉素-用作口服抗生素
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摘要
(A) alpha-Aminobenzylpenicillin esters (I), isomers and acid addn. salts. n = 0-5 A = aliphatic, alicyclic, aromatic or heterocyclic radical, opt. substd. Intermediates (IV) and (VI). Acetoxymethyl and pivaloymethyl esters. The cpds. give high blood and tissue levels of alpha-aminobenzylpenicillin when administered by mouth. Doses: correspg. to 0.1-0.8 g. of D(-)-alpha-aminobenzylpenicillin, given 1 or more times per day.
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机译:(A)α-氨基苄青霉素酯(I),异构体和酸加成基。盐。 n = 0-5 A =脂族,脂环族,芳族或杂环基,同上。取代中间体(IV)和(VI)。乙酰氧基甲基和戊酰甲基酯。 cpds。口服时,血液和组织中的α-氨基苄青霉素含量较高。剂量:correspg。至0.1-0.8g。每天1次或多次服用D(-)-α-氨基苄青霉素。
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