method for preparing a medicine with bactericidal effect that a derivative of 3 - carboxy - dihydrochinolon - 4 contains.product obtained by this method and process for the preparation of these compounds.

摘要

1365839 Cyclopentenoquinoline derivatives BOEHRINGER MANNHEIM GmbH 3 May 1973 [10 May 1972] 21096/73 Heading C2C Novel compounds of Formula I (in which each of R and X is H or saturated or unsaturated, aliphatic C 1-5 hydrocarbyl, Y is OH, C 1-5 alkoxy or C 1-5 acyloxy and Z is H or C 1-5 alkoxy, or Y and Z together represent oxo or C 1-5 alkylenedioxy) and pharmacologically compatible salts thereof, are prepared by cyclizing a compound of the Formula II If desired, the product obtained may be N- alkylated, N-alkenylated or N-alkynylated and/ or rearranged, esterified, ketalized, reduced, oxidized, etherified or acylated to convert it to a different compound I, or it may be converted to a pharmacologically compatible salt. Pharmaceutical compositions having antimicrobial activity comprise a compound I, or a pharmacologically compatible salt thereof, together with a solid or liquid pharmaceutical carrier.