6-Acyloximino-tetrahydro-1,3,4-thiadiazine-2-thiones - with antimicrobial (esp antibacterial) activity against gram positive and negative bacteria

摘要

Cpds. of formula (I): (where R is opt. substd. alkyl or aralkyl; R1 is opt. substd. aryl; R2 is opt. substd. alkyl, aryl, aralkyl or alkenylaryl, or alkoxy, phenoxy, dialkylamino or acylamino) are, pref. prepd. by reacting the corresp. 3-R-5R1-6-oximinotetrahydro-1,3,4-thiodoiazine-2-thione with R2COX (where X is halogen or alkyl-O-CO-O) at 0-150 degrees C, opt. in the presence of a base.