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Cyclocytidine 5'-acetate derivs - prepd by reacting cyclocytidine derivs. with glacial acetic acid
Cyclocytidine 5'-acetate derivs - prepd by reacting cyclocytidine derivs. with glacial acetic acid
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机译:环胞苷5'-乙酸酯衍生物-通过使环胞苷衍生物反应而制备。与冰醋酸
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摘要
Cmpds. (I) are new: (where Y is H, OH, 1-4C alkyl or 1-4C alkoxy; and X is H, halogen or CH3; pref. at least one of X and Y being other than H). This is a Division of 2,244,257. Antivirals and antitumour and anticancer agents. 2,2'-Cyclocytidine (1.0 g) is dissolved (heating) in glacial acetic acid (150 ml) and the soln. is heated 3 hrs. at reflux while water is removed, then let stand overnight in a refrigerator. (I; X=Y=M) (5'-acetyl-2,2'-cyclocytidine) hydrochloride (0.46 g) is precipitated in the form of prismatic crystals, m.pt. 275 degrees or more.
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机译:Cmpds。 (I)是新的:(其中Y是H,OH,1-4C烷基或1-4C烷氧基;且X是H,卤素或CH 3; X和Y中的至少一个不是H)。这是一个2,244,257的分区。抗病毒药,抗肿瘤药和抗癌药。将2,2'-环胞苷(1.0克)溶解(加热)在冰醋酸(150毫升)和溶液中。加热3小时。在回流的同时除去水,然后在冰箱中放置过夜。 (I; X = Y = M)(5′-乙酰基-2,2′-环胞苷)盐酸盐(0.46g)以棱柱状晶体的形式沉淀。 275度以上。
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