From microorganisms of the type of mycobacteria resulting, not - specific irritating agents, which cause a antitumorimmunitaet and a method for the production thereof.

摘要

1438556 Anti-tumour agents AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE 21 May 1973 [19 May 1972] 24047/73 Heading A5B A non-specific agent for stimulating immunity to tumours is obtained from the killed cells of Microbacteria of the species M. tuberculosis var. hominis or bovis; M. Kansasii; M. smegmatis or B.C.G. by treatment to remove lipids with acetone, absolute alcohol and ether and, optionally chloroform and collecting the solid residue. The residue may be subjected to further treatment comprising rupturing the cellular walls and treating with a proteolytic enzyme, the solid residue being the required product. It may be put up into forms suitable for administration by initraderimal or subcutaneous injection or by scarification e.g. aqueous suspension and emulsions thereof with a suitable oil.