the method slightly rauhoittavina medicines useful 5 - phenyl / 5.4 - b / oksatsolidino - two, three, four, five - tetrahydro - 1h - 1,4 benzodiazepine - 2 - onie n for production.

摘要

1276909 Benzodiazepine derivatives. SANKYO CO Ltd 24 Oct 1969 [24 Oct 1968 (2) 17 April 1969] 52353/69 Heading C2C Compounds of the general formula (R 1-3 =H, C 1-5 alkyl, alkoxy, alkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl, halogen, OH, NO 2 , CN, CF 3 , NH 2 , acyl, acylamino, di- (C 1-5 alkyl)amino, acyloxy, COOH, alkoxycarbonyl, NH 2 CO, C 2-6 alkylcarbamoyl, di- (C 1-5 alkyl)carbamoyl; R 4 =H, C 1-5 alkyl, cycloalkyl, aryl, aralkyl, phenacyl; R 5 = H, C 1-5 alkyl; A= alkylene; X = O, S) are prepared by reacting a compound of the formula with a reactive derivative of HOOCCHR 5 Q (Q=acid radical of reactive ester). Quaternary ammonium salts of the formula may be obtained as by-products, and converted to the required compounds by heating. The starting materials may be prepared by reacting a compound of the formula with HXANH 2 . Reference has been directed by the Comptroller to Specification 1,056,423.