procedure for isolation of components in the aqueous losningar by adsorption of the aqueous losningarna on koncentreringshjelpmedel and efterfoljande extraction of components

摘要

1467599 Chromatographic concentration MERCK PATENT GmbH 27 Feb 1975 [2 March 1974] 822875 Heading B1H [Also in Divisions Cl and G1] Components present in aqueous solution, for example drugs or drug metabolites in body fluids are isolated for analysis by adsorption of the components on a concentration agent comprising silica gel and/or Kieselguhr and subsequent extraction of the components with a lipophilic solvent, the concentration agent being a flowable silica gel and/or kieselguhr with an average particle size of 0.05 to 1.0 mm, and average pore volume of 0.2 to 3 ml/g and a specific surface of 0.2 to 50 mSP2/SP/g. The concentration agent may be used as a column packing in a glass or synthetic resin column length 5 to 20 cm, diameter 1 to 3 cm, the packing being retained by wadding or polypropylene mesh. The column may be a syringe barrel. Alternatively the packing may be in pillow- or sphere-shaped bags.