A process for obtaining a derivative of 7-chloro-1,3-dihydro-1-methyl-3-hydroxy-5-phenyl-2H-1,4-benzodia-zepin-2-ona. (Machine-translation by Google Translate, not legally binding)

摘要

A process for obtaining a derivative of 7-chloro-1,3-dihydro-1-methyl-3-hydroxy-5-phenyl-2H-l, 4-benzodiazepin-2-one, characterized in that part of the 7- chloro-1,3-dihydro-1-methyl-3-hydroxy-5-eneyl-2H-1,4-benzodiazepin-2-one, which is reacted in organic medium with 2,5-dicetotetrahydrofuran in the presence of an organic base, and the succinyl derivative obtained is salified in polar organic solvent with n - [(1-ethyl-2-pyrrolidinyl) -methyl] -2-methoxy-5-sulfamoylbenzamide, isolating the final product 7-chloro-1, n - [(1-ethyl-2-pyrrolidinyl) -methyl] -2-methoxy-5-sulfamoylbenzamide] -5-phenyl-2H-1,4-benzodiazepine, 3-dihydro-1-methyl-3- [oxysuccinate] -2-one of developed formula ** (see formula) ** By methods normally used in organic synthesis. (Machine-translation by Google Translate, not legally binding)