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2-n-Butyl-N,N'-diphenyl-malono-monohydrazide prepn. - by ammonia hydrolysis of phenylbutazone
2-n-Butyl-N,N'-diphenyl-malono-monohydrazide prepn. - by ammonia hydrolysis of phenylbutazone
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机译：2-正丁基-N，N′-二苯基-丙二酸单酰肼制备。 -通过氨水解苯基丁hydrolysis
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摘要
The prepn. of 2-n-butyl-N,N'-diphenyl-malono-mono-hydrazide (I) is carried out by hydrolysing 3,5-dioxo-1,2-diphenyl-4-n-butyl-pyrazolidine (II) with aq. NH4OH or a NH4OH-releasing salt (e.g. (NH4)2CO3), pref. at 100 degrees C. Malono-monohydrazides are useful as antiphlogistic and antipyretic agents. Yields of 90-95% are obtained in shorter reaction times (1-5 hr.) than when alkali metal hydroxide is used (c.f. DT 1235936). The reaction is pref. effected by refluxing 1 mole (II) with 1-2 moles NH4OH or (NH4)2CO3 in a 3- to 6-fold amt. of H2O.
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机译：的准备。 2-N-丁基-N，N'-二苯基-丙二醛-单酰肼（I）的制备是通过将3,5-二氧-1,2-二苯基-4-正丁基-吡唑烷（II）水解水NH4OH或释放NH4OH的盐（例如（NH4）2CO3），优选。在100℃下，丙二酰一肼可用作消炎药和退热药。与使用碱金属氢氧化物相比（参见DT 1235936），在较短的反应时间（1-5小时）内可得到90-95％的产率。反应是优选的。通过将1摩尔（II）与1-2摩尔NH 4 OH或（NH 4）2 CO 3在3至6倍的amt中回流来实现。的水。
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