5-Amino-5-(N-formylcarbamoyl)-pyrazole derivs. of formula (I) (where alk is opt. branched -15C alkylene; n is 0 or 1; and R3 is a heterocyclic residue having aromatic character, or a partially or pre-hydrogenated deriv. of such a residue), e.g. 5-amino-3-formylcarbamoyl-1-nicotinoylpyrazole, 5-amino-3-formylcarbamoyl-1-(2,4-dioxo-1, 2,3,4-tetrahydro-6-pyrimidinylcarbonyl)-pyrazole and 5-amino-3-formylcarbamoyl-1- 2-1(1,3,5-triphenyl-1H-pyrazol-4-yl)- -acetyl -pyrazole, and their salts are new cpds. (I) are xanthine oxidase inhibitors with considerably lower acute toxicity than allopurinol, and are useful in the treatment of gout.
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机译：5-氨基-5-（N-甲酰基氨基甲酰基）-吡唑衍生物。式（I）的通式（I1）（其中alk是任选的支链-15C亚烷基; n是0或1; R 3是具有芳族特性的杂环残基，或该残基的部分或预氢化的衍生物），例如5-氨基-3-甲酰基氨基甲酰基-1-烟酰基吡唑，5-氨基-3-甲酰基氨基甲酰基-1-（2,4-二氧代-1、2,3,4-四氢-6-嘧啶基羰基）-吡唑和5-氨基- 3-甲酰基氨基甲酰基-1-2-1（1,3,5-三苯基-1H-吡唑-4-基）-乙酰基-吡唑及其盐是新的cpds。 （I）是黄嘌呤氧化酶抑制剂，其急性毒性比别嘌呤醇低得多，可用于治疗痛风。
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