Ethylenic piperonal alcohols and ketones - anxiolytics, antidepressants, hypnotics and tranquillisers

摘要

Piperonal derivs. have formula (I): (where R1=H, R2=OH, R3=H, halogen, OH, NO2 or CH3O, R4=alkyl, of 1-6C, opt. substd. by OH or phenyl which may be substd. by one or more methyl, hydroxy, methoxy or allyloxy gps., but when R3=H, R4 is not = tert. butyl). The cpds. have activity on the central nervous system, esp. as anxiolytics, antidepressants, hypnotics, and tranquillisers.