Imidazo 2,1-a isoquinolin-5-ol derivs. of formula (I) (where R0 is H, F or Cl, and R, R1 and R2 are H, F, Cl, CH3, OCH3 or CF3, or R + R1 or R1 + R2 is methylenedioxy, in which case R0 and R2 are H; and R3 is H, F, Cl or CH3; provided that when R or R2 is CF3, then R1 is H, F or Cl, and that is not 2 of R0, R, R1 and R2 are other than H), e.g. 5-(p-fluorophenyl)-2,3,5,6-tetrahydroimidazo 2,1-a isoquinolin-5-ol, are new cpds. They are prepd. by reacting dilithium dervis. (II) of 2-(p-R3-o-tolyl)-2-imidazoline swith substd. benzoyl halides or benzoic acid 1-4C alkyl esters. The dilithium derivs. (II) are new. (I) have CNS stimulant and appetite suppressant activity.
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机译：咪唑2，1-a异喹啉-5-醇衍生。式（I）的通式（其中R 0是H，F或Cl，并且R，R 1和R 2是H，F，Cl，CH 3，OCH 3或CF 3，或者R + R 1或R 1 + R 2是亚甲二氧基。 R2为H; R3为H，F，Cl或CH3;条件是当R或R2为CF3时，R1为H，F或Cl，且R0不大于2，R，R1和R2不是H），例如5-（对氟苯基）-2,3,5,6-四氢咪唑2,1-a异喹啉-5-醇是新的cpds。他们准备好了。通过使双锂电反应。 （II）2-（对-R3-邻甲苯基）-2-咪唑啉的取代基。苯甲酰卤或苯甲酸1-4C烷基酯。二锂衍生。 （II）是新的。 （I）具有中枢神经系统兴奋剂和食欲抑制活性。
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