1504132 2 - Bromo - 6# - fluoro - pregnane compounds G PALLADINO 24 Feb 1975 [8 March 1974] 10443/74 Heading C2U Novel steroids have the formula wherein X is oxo, #-OH or #-Cl; Y is F or Cl but is not F when X is Cl; RSP1/SP is H or C 2-8 alkanoyl; Z is H, - or #-CH 3 , -OH or, when RSP1/SP is H, -O-(C 2-8 alkanoyl); and R is H, C 2-8 alkanoyl optionally containing a CO 2 H group, m-sulphobenzoyl or phosphono. They are prepared as illustrated in the following reaction scheme wherein Ac is acetyl and RSP1/SP is H or C 2-8 alkanoyl. 21-Ols may be acylated by standard procedures. The preparation of starting materials is described, and some of them are claimed, in Specifications 1,504,133 and 1,504,134. The novel steroids are anti-inflammatory agents, and they may be made up into pharmaceutical compositions with suitable carriers.
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