Cpds of formula (I) and their 1,2-dehydro deriv. (where R6 and R9 are H, F, Cl or Br; R17 and R21 are OH or acyloxy; Z is CO or beta-hydroxymethylene are prepd by hydroxylating (I;R21=H), or its 1,2-dehydro deriv, in the 21-posn; or by oxidising the 11alpha-OH in (I; R9=H, Z=alpha-hydroxymethylene), or its 1,2-dehydro deriv, into an oxo gp. The prefd starting materials is 11beta,17beta-dihydroxy-15beta,16beta-methylene pregn-4-en-3,20-dione or its 1,2-dehydro deriv. (I) have anti-inflammatory activity.
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