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Microencapsulated or embedded medicaments prodn - by dispersing org. soln. of medicament and wall matl in carrier
Microencapsulated or embedded medicaments prodn - by dispersing org. soln. of medicament and wall matl in carrier
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机译:微囊化或包埋药物生产-通过分散组织。 soln。载体中的药物和壁基质
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摘要
Encapsulated or embedded medicaments are produced by (a) dissolving a hydrophobic wall matl. (pref. a non-toxic synthetic high-mol. polymer) in =1 water-immiscible org. solvent having a b.pt. is not 100 degrees C, a vapour pressure greater than that of water and a dielectric constant is not 10, (b) dissolving or dispersing in the resulting soln. a medicament which is water-insol. or has a low solubility in water, (c) dispersing the resulting soln. or dispersion in a carrier (pref. an aq. hydrophilic colloid and/or an aq. anionic surfactant) so as to form fine droplets, and (d) evapg. the org. solvent. The process gives microcapsules under mild conditions so that the medicament is not decomposed. The microcapsules give excellent masking of unpleasant flavours and odours and improve the stability of the medicament. The microcapsules are so fine that they can be treated as dust-fine powders, and individual microcapsules contain practically identical amts. of medicament, making them partic. suitable for medicinal use.
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