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Diazabicyclooctanes and diazabicycloheptanes
Diazabicyclooctanes and diazabicycloheptanes
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机译:二氮杂双环辛烷和二氮杂双环庚烷
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摘要
Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo 3.2.1!octane, 2-methyl-2,5- diazabicyclo 2.2. 2!octane, and 2-methyl-2,5-diazabicyclo 2.2.1!heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.
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