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New process for preparing ethers Basic 2,2-dimethyl - 4 - phenyl - chromane and its Salts
New process for preparing ethers Basic 2,2-dimethyl - 4 - phenyl - chromane and its Salts
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机译:制备碱性2,2-二甲基-4-苯基苯甲烷及其盐类醚的新工艺。
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摘要
Compounds of the formula II are prepared IMAGE in which X is alkylene having 2 to 4 carbon atoms, Y is an oxygen or sulphur atom or a CH2 group; R1 is a hydrogen atom or lower alkyl; R2 is a hydrogen atom, lower alkyl, phenyl, tolyl or benzyl, or R2 is bonded to R1 with the formation of a 5-, 6- or 7-membered ring; R3 is aryl, aralkyl or a pyridyl, furyl, thienyl or pyrrolidyl radical, R4 is a hydrogen atom or C1-4-alkyl and R5 is a hydrogen atom or C1-4-alkyl, by reaction of an appropriate 7-OH compound with a compound Q1-X-NR1R2 or a compound Q1XQ2, in which Q1 and Q2 are groups which are easily removable by a nucleophile, and subsequent reaction with an amine HNR1R2. The compounds prepared according to the invention act on the central nervous system. Depending on the dose administered, they act as appetite suppressants or affect the mood of the person.
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