Process for the preparation of Acid 6 - (4-chlorophenyl) - 2,2-dimethyl - 7 - phenyl - 2,3 dihydro - 1H - pirrolizin - 5 - L - acetic acid and Process for preparing 6 - (4-chlorophenyl) - 2,2-dimethyl - 7 - phenyl - 2,3 dihydro - 1H - and pirrolizina 2 - Benzyl - 4.4 - dimethyl-1 - used in The previous pirrolina

摘要

A procedure for the preparation of acid, 6 - (4-chlorophenyl) - 2,2-dimethyl - 7 - phenyl - 2,3 dihydro - 1H - 5 - acetic pirrolizin il of the formula (1),Comprising: (a) to transform the compound of the formula (4) in the compound of the formula (3) as follows: A1) is catalytically Hydrogenated Compound of the formula (4) or A2) into the compound of the formula (4) in the ketal of formula (5) where IGU remains R, which can be Ales or different, represent c1-4 alkyl or together alquileno C2 - 3The ketal and Hydrogenated catalytically Transform, (b) The Compound of formula (3) with W - Bromine - 4 - CHLOROACETOPHENONE 54 in a compound of the formula (2) and (c) introduce a rest of acetic acid in the compound of the formula (2).The ML 3000 is a very promising inhibitory substance of the cyclooxygenase and 5-lipoxygenase and is therefore suitable for the treatment of Rheumatic Diseases Group forms and for Preventive Treatment of allergic Diseases induced.