preparations with a basis of calcitonin, a prolonged action

摘要

Case 4-9910/+ CANADA PEPTIDE PREPARATIONS WITH PROLONGED ACTION The invention is directed to calcitonin preparations with prolonged action which are characterized by the presence of a calcitonin with hypocalcemic activity having an isoelectric point in the pH range of about 5 to 9, in the form of a suspension of the sparingly soluble free peptide base in an aqueous or oily liquid. There are used for instance suspensions of Calcitonin M or a derivative or analog thereof, preferably containing 0.1 to 5 mg/ml of the peptide base. The invention also includes a method for the treatment of pathological conditions in humans for whom the administration of a calcitonin is indicated, such as Paget's disease, by administering the suspensions of the invention by the subcutaneous or intramuscular route.