12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium

摘要

Dehydroxylation of 12, dihydroxysteroids (II) to (I) consists of using 12-dehydroxylase enzyme. (where X = H, OH, acyloxy, alkoxy or oxo; R = OH, acyloxy, alkoxy, taurine or glycine). The enzyme may be produced by cultivation of clostridium perfringens. Some (I) have hypolipidaemic activity.