method for the preparation of corticoide ste - roiden, method for preparation of trime - thylsiloxysteroiden, method to create the preparations that contain these compounds inand the obtained formed preparations.

摘要

A procedure for converting steroids characterized by presence of an 11 beta OH group into potent corticoids having one or more substituents, such as 6 alpha F, 16 alpha , 17 alpha -hydroxy or isopropylidene dioxy, 16 alpha or 16 beta methyl, DELTA 1,4; by reacting the 11 beta -hydroxy steroid with trichloromethyl siloxane steroid, thereby rendering the normally sensitive 11 substituent inert to the series of reactions which thereafter incorporate one or more of the desired above listed substituents into the steroid molecule. The siloxy group is then hydrolyzed to regenerate the 11 beta -hydroxy substituent.