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16,16-Dimethyl 9-oxo-11-hydroxymethyl-15-hydroxyprosta- 5(cis), 13(trans)-dienoic acid derivatives and process for the preparation thereof

机译:16,16-二甲基9-氧代-11-羟基甲基-15-羟基前列酯5(顺式),13(反式)-二烯酸衍生物及其制备方法

摘要

Prostanoic acid derivatives having the formula ##STR1##wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R.sup.1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R.sup.2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof.PPThe compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R.sup.1 and R.sup.2 are the same as above, R. sup.3 and R.sup.4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.
机译:具有式## STR1 ##的扁桃酸衍生物,其中A表示具有1-5个碳原子的直链或支链的亚烷基,R 1表示具有4-10个碳原子的直链或支链的烷基和R。 sup.2表示氢原子或具有1至6个碳原子的直链或支链烷基及其药学上可接受的盐。化合物可用作氧疗剂和抑制胃酸分泌的试剂,并且可以通过氧化具有式## STR2 ##的化合物制备,其中A,R.1和R.2与上述相同,R.3和R.4相同或不同,并且各自代表羟基的保护基,以得到具有式## STR3 ##的化合物,其中A,R 1,R 2,R 3和R 4相同如上所述,从后一种化合物中除去羟基保护基,并在合适的情况下使如此获得的产物成盐。

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