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N,N-bis2-(3-substituted-4-hydroxyphenyl)-ethyl or -2- hydroxyethyl- polymethylenediamines
N,N-bis2-(3-substituted-4-hydroxyphenyl)-ethyl or -2- hydroxyethyl- polymethylenediamines
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机译:N,N-双[2-(3-取代的4-羟苯基)-乙基或-2-羟乙基]-聚亚甲基二胺
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摘要
N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2- hydroxyethyl]- polymethylenediamines having -adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an -bromoacetophenone with an N,N'-dibenzyl- polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on- carbon. The key intermediates are also part of the invention.
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