首页>
外国专利>
FOERFARANDE FOER FRAMSTAELLNING AV INTRAVENOEST APPLICERBART SERUMAEGGVITE-PREPARAT
FOERFARANDE FOER FRAMSTAELLNING AV INTRAVENOEST APPLICERBART SERUMAEGGVITE-PREPARAT
展开▼
机译:静脉滴注血清白蛋白的制备程序
展开▼
页面导航
摘要
著录项
相似文献
摘要
A process of preparing a serum protein composition for intravenous application or administration, in which process, starting from a human blood protein solution, a stabilized, universally applicable preparation or composition is prepared which contains dissolved in an aqueous isotonic solution, such proteins in which the ratio of globulins and albumins corresponds substantially to that of the native blood serum, in the following steps: (a) fractionation of human blood plasma upon removal of coagulation factors according to a process known per se recovering thereby precipitates and supernatants of different fractionation steps, (b) mixing and resolving of precipitates of different fractionation steps, preferably the COHN-fractions IV, III-1 and III-2), in which blood proteins, especially albumin and globulins, are preserved in a native form, said precipitates mixed and resolved in a chemically and physiologically adapted solvent, said solvent eventually containing also supernatants of the fractionation steps, (c) adjustment of the mixture to a content of 50-70% albumin and 30-50% globulin, related to the entire protein content, (d) stabilizing, purification and drawing off the preparation in a suitable manner.
展开▼