process for the preparation of dioxatri cyclo (- 2.9 - 4,3,1,03 deans, 7).

摘要

A process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,03,7] decane derivatives is disclosed, wherein a 10-methylen-3-iodomethyl compound of the formula IMAGE is hydrogenated to obtain a mixture of the corresponding epimeric 10 beta - and 10 alpha -methyl-3-iodomethyl compounds, the pure 10 alpha - and 10 beta -methyl epimers are separated and recovered from this mixture and are reacted with a secondary amine. Optionally, the substituent in the 4-position of the resulting 10 alpha - or 10 beta -methyl-3-aminomethyl compounds are further changed.