CLAVULANIC ACID, SALTS, ESTERS AND PREPARATION THEREOF FROM STREPTOMYCES CLAVULIGERUS: PHARMACEUTICAL COMPOSITIONS

摘要

A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): IMAGE (I) In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of beta -lactam antibiotics against many beta -lactamase producing bacteria.