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process for the production ossime derived from 7 - amino acid and pharmaceutical compositions which contain as the active ingredient tiazolil acetammido cefalosporanico
process for the production ossime derived from 7 - amino acid and pharmaceutical compositions which contain as the active ingredient tiazolil acetammido cefalosporanico
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机译:衍生自7-氨基酸的ossime的方法和包含作为活性成分的替扎洛尔乙酰胺基头孢氨苄的药物组合物
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摘要
The compounds correspond to the formula: IMAGE in which the symbols R, R1 and A have the meaning given in Claim 1. They are prepared by reacting compounds of formula II and III: IMAGE or a functional derivative of III, in which A' represents H or an ester which can be removed by acid hydrolysis or by hydrogenolysis, R2 represents a group which can be removed in the same way or a chloroacetyl group and R'1 is defined like R2 or represents a saturated or unsaturated C1-C4 alkyl and when R'1 represents ClCH2CO-, R2 also represents this group; the removable groups A', R2 and R'1 are then removed by acid hydrolysis, hydrogenolysis and/or treatment with thiourea. The compounds and their salts of the carboxylic group have a good antibiotic activity and can be used for the treatment of various infectious diseases.
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