COPOLYMERS BASED ON N-SUBSTITUTED ACRYLAMIDES, N-SUBSTITUTED METHACRYLAMIDES AND N,N. DISUBSTITUTED ACRYLAMIDES AND THE METHOD OF THEIR MANUFACTURE

摘要

ABSTRACT OF THE DISCLOSURE:Copolymers consisting of (a) 39.9 to 99.9 molar percentof units of the general formula A, formed by a basic monomerselected among N-substituted acrylamideo, N-substituted meth-acrylamides and N, N-disubstituted acrylamides,(A)where R1 is H or CH3, R2 is an alkyl or alkoxyalkyl radical ha-ving from one to six carbon atoms and substituted or not with upto three OH groups, and R3 is H or R2 when R1 is H, or R3 is Hwhen R1 is CH3; (b) 0.1 to 50 molar percent of units X formedby copolymerization with a monomer selected from the group compri-sing: ,wherein R4 is hydrogen or methyl, R5 is a residue of p-nitro-phenol, 2,3,5-trichlorophenol, 8-hydroxyquinoline, N-hydroxy-succinimide or N-hydroxyphthalimide, and n = 0 to 4, , where in x = 2 to 10, , and ,wherein the substituents R4 and R5 have the aforesaid meanings;and (c) 0 to 60 molar percent of units Z formed by copolymeriza-tion with a divinyl compound selected from the group comprisingbis-acrylamides, bismethacrylamides, bis-acrylates, ethyleneglycol dimethacrylate, diethylene glycol dimethacrylate, 1,4-cyclohexyldimethyl dimethacrylate, 1,6-hexamethylene-bis-acryla-mide, 1,6-hexamethylene dimethacrylate, N,N-methylene-bis-acryla-mide, N,N-ethylene-bis-methacrylamide, tetraethylene glycol dis-crylate, tetraethylene glycol dimethacrylate, tetramethylene dis-crylate, 1,1,1-trimethylolethane trimethacrylate, 1,1,1-trime-thylolpropane triacrylate, 1,1,1-trimethylolpropane trimethacryla-te, diisopropylene glycol dimethacrylate, ethylidene diacrylate,ethylidene dimethacrylate, divinylsulfone and triacryloylperhydro-triazine. These copolymers an particularly useful for the bondingof biologically active compounds. Copolymers containing thedivinyl component (c) are suitable for use as separation membranesor as packings for columns for the gel or affinity chromatography.