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Substd. benzyl pyrimidine prepn. from a cyanoacetate and guanidine - for use as a synergist with sulphonamides in control of coccidiosis in poultry
Substd. benzyl pyrimidine prepn. from a cyanoacetate and guanidine - for use as a synergist with sulphonamides in control of coccidiosis in poultry
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机译:取代。苄基嘧啶制备。从氰基乙酸盐和胍中提取-与磺胺类增效剂一起用于控制家禽球虫病
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摘要
(III) is prepared by condensing ethyl (2-methyl-4,5-dimethoxybenzyl)cyanoacetate or diethyl(2-methyl-4,5-dimethoxybenzyl)melonate with guanidine or urea to give (I). The free amino groups are protected by acetylation and the protected (I) chlorinated with POCl3 or PCl5 to give (II) which is then aminated and catalytically dehalogenated with H2 in the presence of Pd/C to give (III) (where Z'=2-methyl-4,5-dimethoxybenzyl; R'=CN or CO2-Et; X and Y = same or different OH or NH2; Z and W = same or different Cl or NH2).
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