Agonist analogues of luteinizing hormone releasing hormone

摘要

Novel peptide compounds of the formula ##EQU1## are provided together with their acid addition salts and their complexes with pharmaceutically acceptable metals. The compounds are LH-RH analogues and together with their salts and complexes exhibit LH-RH agonist activity. In the formulaPPX.sup.3 and X.sup.5 are the same or different and each is phenylalanyl optionally substituted in the benzene ring; PPX.sup.4 and X.sup.6 are the same or different and each is selected from glycyl, alanyl (D- or L-) and asparaginyl;P P X.sup.7 is a radical of a neutral hydrophobic nonsulphur containing non- heterocyclic amino acid;PPX.sup.8 is a radical of a basic amino acid or is glycyl or phenylalanyl optionally substituted in the benzene ring; andPPW is selected from glycine amide and a group --NR.sup.1 R.sup.2.PPAll references are to the L- amino acids and their radicals except in the case of glycine and unless otherwise stated.PPAlso provided are methods for the preparation of the peptides, salts and complexes, pharmaceutical formulations containing them and methods for the preparation of such formulations, and methods for the use of the peptides, salts and complexes in human and in veterinary medicine.