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Water insoluble hydroxyethyl methacrylate hydrogels - with low diester content, are soluble in methanol and useful e.g. as burn dressings
Water insoluble hydroxyethyl methacrylate hydrogels - with low diester content, are soluble in methanol and useful e.g. as burn dressings
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机译:具有低二酯含量的水不溶性甲基丙烯酸羟乙酯水凝胶可溶于甲醇,例如可用于有机溶剂。作为烧伤敷料
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摘要
Solid water-insoluble, methanol-soluble, hydrophilic polymers are made by polymerising a monomer HO-R-O-CO-C(R')=CH2 (I) (where R is2-3C alkylene group and R' is H or Me), in the presence of water with is not 0.035 wt. % (on wt. of monomers) of a diester of formula: H2C=C(R')-CO-O-R-O-CO-C(R')=CH2 (II). Pref. monomer (I)is 2-hydroxyethylmethacrylate (III) and the diester (II) is ethyleneglycoldimethacrylate (IV). Polymerisation is carried out e.g. using a free radical initiator and with a ratio of (III) to water of 10:90 to 70:30, esp. about 35:65 to give a polymer with a mol. wt. of about 250,000. The polymers are porous in nature and can easily be washed to a high degree of purity. They are insoluble in water but dissolve in solvents such as (m)ethanol, isopropanol, ethylene glycol, diethylene glycol, etc. The purified polymers are esp. useful for medical applications such as carriers or encapsulating agents for germicides, fungicides, antibiotics, analgesics, etc. In micropulverised form, the polymers are useful in the prepn. of burn dressings.
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机译:通过聚合单体HO-RO-CO-C(R')= CH2(I)(其中R为2-3C亚烷基,R'为H或Me)制得不溶于水,溶于甲醇的亲水性固体聚合物,在水存在下,不大于0.035重量%。式(H 2 C = C(R′)-CO-O-R-O-CO-C(R′)= CH 2(II)的二酯的%(按单体的重量计)。首选单体(I)为甲基丙烯酸2-羟乙酯(III),二酯(II)为亚甲基丙烯酸乙二醇酯(IV)。聚合例如进行。使用自由基引发剂,并且(III)与水的比例为10:90至70:30,特别是约35:65得到具有摩尔数的聚合物。重量 250,000。聚合物本质上是多孔的,可以容易地洗涤到高纯度。它们不溶于水,但溶于溶剂如(间)乙醇,异丙醇,乙二醇,二甘醇等。纯化的聚合物尤其是。可用于医疗应用,例如杀菌剂,杀真菌剂,抗生素,镇痛药等的载体或包封剂。以微粉形式使用时,聚合物可用于制备。烧伤敷料。
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