PROCESS FOR ISOLATING THE ANTIGENIC FRACTION OF SCHISTOSOMA MANSONI EGGS AND THERAPEUTIC APPLICATION

摘要

Method for isolating the antigen fraction of mature eggs of Schistosoma mansoni. /P P Mature eggs of Schistosoma mansoni are crushed to release soluble antigens, which are fractionated and purified by absorption, gel filtration and / or ion exchange chromatography and then carries out a radioactive labeling with ** 125I. One fraction, identified as MSA1, is specific for the stage of maturity of Schistosoma mansoni eggs. Application to the determination of the presence of antibodies in patients suspected of being infected, and also to the differentiation between the species of schistosomes (specificity of species) and between stages of maturity or non-maturity of the eggs (specificity of the stage of evolution).