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Synthesis of 6-amino-4-methyl-8-(-D-ribofuranosyl)pyrrolo 4, 3,2- de!pyrimido 4,5-C!pyridazine-5'-phosphate as a novel compound and its utility against L-1210 mouse leukemia
Synthesis of 6-amino-4-methyl-8-(-D-ribofuranosyl)pyrrolo 4, 3,2- de!pyrimido 4,5-C!pyridazine-5'-phosphate as a novel compound and its utility against L-1210 mouse leukemia
The compound 6-amino-4-methyl-8-(-D-ribofuranosyl)pyrrolo 4,3,2- de!pyrimido 4,5-c!pyridazines-5'-phosphate (a nucleotide) as a new compound and its method of synthesis by phosphorylation of the known 6- amino-4-methyl-8-(-D-ribofuranosyl)pyrrolo 4,3,2-de!pyrimido 4,5- c!pyridazine (a nucleoside). The 5'-phosphate ester has utility against L- 1210 mouse leukemia and has superior solubility over the parent compound which gives it a broader use pattern relative to dosage. This novel nucleotide also shows advantage in utilization as to pH over, for example, the hydrochloride salt which gives in solution a pH of 4 and is too acid for use.
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