Imidazo 4,5-c quinolin-1 - 4 - amines and tetrahidroimidazo 4,5-c quinolin-1 - 4 - amines, Pharmaceutical compositions that include the use of such compounds in preparation of Medicines and Intermediates useful in the synthesis of such compounds

摘要

Imidazo [4,5-c] quinolin-1 - 4 - amines and tetrahidroimidazo [4,5-c] quinolin-1 - 4 - amines of formula (1), in which the links are represented by dotted lines are present or Absent, X is - chr5 chr5 alkyl -, -, - or - chr5 alquenilo; r1 is selected the Group consists of Cr3 - Z - R6 R4 - alkyl R4, R6 z Cr3 - - - - - - alquenilo Cr3, R4 Z - R6 R4 - aryl, heteroaryl Cr3 - Z - R6 R4, R6 z Cr3 - - - - heterociclilo,R4 - Cr3 - Z - H, - - - nr7 Cr3 R4 R6 alkyl R4, R6 nr7 Cr3 - - - - - - alquenilo R4, R6 nr7 Cr3 - aryl - - - - nr7 Cr3, R4 R6 R4 - heteroaryl, nr7 Cr3 - - - - - heterociclilo R4 R6, and nr7 - Cr3 - R8; each is independently NR5 - Z -, - O -, - S -; R2 is selected from the group consisting of hydrogen, alkyl, aryl, alquenilo, heteroari So, heterociclilo, alkyl and alkyl, alkyl and alkyl aryl - and alquenilo,,And alquenilo alkyl or substituted with one or more substituents selected from the group consisting of oh Halogen (R5), N, n 2, CO 2, CO (R5) C1 - 10 co alkyl, o-alkyl C1 - 10, N3, aryl, heteroaryl, aryl heterociclilo, co, and CO - heteroaryl; each is R3 = r4 = o or s; each is independently alkyl Or alquenilo,That can be interrupted by one or More groups or R5; each is independently H or alkyl of C1 - 10; R6 is a Link, alkyl, or alquenilo, which can be interrupted by one or More groups - or - C1; R7 is H, alkyl - 10Or arylalkyl or R4 and R7 can be United to form a Ring; R8 is H or alkyl of C1 - 10; and R7 and R8 may join together to form a ring, and each is independently - or or - S (o) 0 - 2 -; n is 0 to 4 and each R is present; independently selected from the group consisting of alkyl C1 - 10, Lac Oxy Hydroxy, halogen C1 - 10, and pharmaceutically acceptable Salts triflu00faormetilo; or the same.These compounds are useful as immune response modifiers. These compounds can induce the biosynthesis of several cytokines and are useful in the treatment of a variety of disorders including Viral Diseases and neoplastic diseases.Also disclosed are Pharmaceutical compositions that include the use of such compounds in preparation of Medicines and Intermediates useful in the synthesis of such compounds.