N ALPHAAALKYLSULFONYL OMEGAAAMIDINOPHENYLL ALPHAAAMINOALKYL CARBOXYLIC ACID AMIDE AND N ALPHAAAMIDINOPHENYLLALPHAAAMINOALKYL CARBOXILIC AMIDE

摘要

Compounds of the general formula:- IMAGE wherein R1 is an alkylsulphonyl radical containing up to 6 carbon atoms or an arylsulphonyl radical containing 6 to 10 carbon atoms, R2 is a hydrogen atom, an alkyl radical containing up to 8 carbon atoms, an aryl radical containing 6 to 10 carbon atoms or an aralkyl radical containing up to 3 carbon atoms in the side chain, R3 is an alkyl radical containing up to 8 carbon atoms, an aryl radical containing 6 to 10 carbon atoms or an aralkyl radical containing up to 3 carbon atoms in the side chain, or R2 and R3, together with the nitrogen atom to which they are attached, can also form a 5- to 7-membered heterocyclic ring-which can contain one or more further heteroatoms and/or can be substituted and n is 0, 1, 2 or 3; as well as the acid-addition salts thereof with physiologically acceptable inorganic and organic acids have anticoagulant activity.