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AMINOO33CARDENOLIDE DERIVATIVES*THEIR MANUFACTURE AND MEDICINES CONTAINING THEM
AMINOO33CARDENOLIDE DERIVATIVES*THEIR MANUFACTURE AND MEDICINES CONTAINING THEM
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机译:氨基33羧化物*它们的制造和药物
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摘要
Amino-3-cardenolide derivatives represented by the general formula (I) IMAGE (I) wherein n and m, which may be the same or different, each represents an integer from 0 to 4; R1, R2, R4, R5 and R6, which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R3 represents a lower alkyl, aldehyde, haloalkyl, hydroxyalkyl, acyloxyalkyl, or ethylenedioxyalkyl group; R7 represents a hydrogen atom or an alkyl group; R8 represents a hydrogen atom or an alkyl, acyl, alkyloxycarbonyl or aralkoxycarbonyl group; R9 represents a hydrogen atom or an alkyl group; R8 and R9 can combine and form with the nitrogen atom a heterocyclic ring; R10 represents a hydroxy, alkoxy or aralkoxy group, an amino residue of amino acid or of an oligo-peptide, useful especially for the treatment of cardiac ailments.
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机译:通式(I)(I)表示的氨基-3-心烯内酯衍生物,其中n和m可以相同或不同,各自表示0至4的整数; R 1,R 2,R 4,R 5和R 6可以相同或不同,分别表示氢原子或羟基,烷氧基或酰氧基。 R3代表低级烷基,醛,卤代烷基,羟烷基,酰氧基烷基或亚乙二氧基烷基; R 7表示氢原子或烷基。 R8代表氢原子或烷基,酰基,烷氧羰基或芳烷氧羰基; R 9表示氢原子或烷基。 R8和R9可与氮原子结合并形成杂环; R 10代表羟基,烷氧基或芳烷氧基,氨基酸或寡肽的氨基残基,特别用于治疗心脏病。
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