PROCESS FOR PURIFYING VINCRISTINE, DES-N-METHYL-VINBLASTINE AND VINBLASTINE ALKALOIDS FROM THE LEAVES OF VINCA ROSEA

摘要

Dimeric indole alkolids-vinblastine, des-N-methyl-vinblastine and vincristine-are purified by extracting leaves of Vinca rosea with acid, neutralizing the acidic solution, extracting the dimeric alkaloids into an aromatic solvent, optionally subjecting the extracted alkaloids to gel exclusion chromatography, precipitating the dimeric alkaloids as sulfate salts and finally separating the dimeric alkaloids by high- pressure chromatography.