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SYNERGISTIC ANALGETIC COMPOSITIONS CONTAINING AN INDOLE ACETIC ACID DERIVATIVE AND A NARCOTIC OR ANTI- NARCOTIC ANALGESIC COMPOUND
SYNERGISTIC ANALGETIC COMPOSITIONS CONTAINING AN INDOLE ACETIC ACID DERIVATIVE AND A NARCOTIC OR ANTI- NARCOTIC ANALGESIC COMPOUND
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机译:包含吲哚乙酸衍生物和麻醉性或麻醉性麻醉性化合物的协同麻醉剂组合物
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摘要
An alalgetic composition which comprises, as an active ingredient, a therapeutically effective amount of a synergistic mixture of an indole-3- acetic acid derivative of the formula, ##STR1## wherein R is a halobenzoyl, piperonyloyl or cinnamoyl group and R.sub.1 is a 5- methoxy or 5,6-methylenedioxy group; and a narcotic or anti-narcotic analgesic selected from the group consisting of a compound of the formula, ##STR2## wherein R.sub.2 and R.sub.3 are each a C.sub.1 - C.sub.3 alkyl group and R.sub.4 is a 4-(4-fluorophenyl)-4-oxobutyl, cyclopropylmethyl or 3-methyl- 2-butenyl group; a compound of the formula, ##STR3## wherein R.sub.5 is a hydrogen atom or a C.sub.1 - C.sub.3 alkyl group; a compound of the formula, ##STR4## and a compound of the formula, ##STR5## wherein R.sub.6 is a C.sub.1 - C.sub.3 alkyl group; and a pharmaceutically acceptable carrier or diluent and its preparation and a method of obtaining analgesia which comprises administering the same to a patient.
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