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method for preparing a therapeutic preparation with antibiotic activity and / or cytostatic activity against tumor cells formed preparationmethod for preparing for the win and werkijze appropriate connections.
method for preparing a therapeutic preparation with antibiotic activity and / or cytostatic activity against tumor cells formed preparationmethod for preparing for the win and werkijze appropriate connections.
1,194,238. Alkyl--glyceryl ethers. ASTRA NUTRITION A.B. 15 Dec., 1967 [16 Dec., 1966], No. 57149/67. Heading C2C. The invention comprises compounds of the Formula (I) where RSP1/SP and RSP2/SP are the same or different and represent hydrogen or aliphatic acyl groups of at most 24 carbon atoms, one of RSP3/SP and RSP4/SP is hydrogen and the other is an alkoxy or alkenyloxy group of at most 7 carbon atoms and RSP5/SP represents a straight or branched, saturated or mono- or poly-unsaturated aliphatic group of 4 to 21 carbon atoms. They are extracted from naturally occurring lipid products containing -glyceryl ethers, such as liver oils from Greenland shark, dog-fish, rat-fish, by distributing the lipid product, preferably after prepurification by removal of hydrocarbons and saponifiable constituents, between two media forming separate phases comprising an operation consisting of a preferably repeated extraction using two partially miscible liquids or chromatography of the lipid product in a solvent on a solid adsorbent such as silicic acid or deactivated aluminium oxide or treating the lipid product in a solvent with a substance capable of forming inclusion compounds with some part of the glyceryl ether mixture or by fractional crystallization from a polar solvent. Compounds of Formula (I) may be prepared by reacting a compound of the formula with a compound of the formula wherein RSP3#1/SP, RSP4#1/SP and RSP5#1/SP represent RSP3/SP, RSP4/SP or RSP5/SP respectively or an atom or group capable of being transformed into RSP3/SP, RSP4/SP or RSP5/SP respectively by methods known in the literature, RSP7/SP represents an oxygen atom, a carbon-carbon bond or the group where RSPa/SP represents hydrogen or alkyl, RSPb/SP represents alkyl or aryl and RSPa/SP and RSPb/SP together may form a ring which may contain a hetero atom and X and Y are a pair representing the pairs of groups (a) hal, and -OM, (b) arylsulphonyl and -OM, (c) alkylsulphonyl and -OM, and (d) hydroxy and hydroxy, where that means halogen, preferably chlorine or bromine, and M is a positively charged atom or group, preferably K, Na or Li, to form a compound of the formula whereafter if any of RSP3#1/SP , RSP4#1/SP and RSP5#1/SP differ from RSP3/SP, RSP4/SP and RSP5/SP respectively, the differing groups are transformed into the predetermined group and whereafter the group is transformed to the group CH 2 ORSP1/SP, CHORSP2/SP- by methods known in the literature. 2-Methoxy (or 2-ethoxy) hexadecyl p-toluenesulphonate is prepared by reacting p-toluenesulphonyl chloride with 2-methoxy (or 2- ethoxy) hexadecanol. 2 - Methoxy - hexadecanol - 1 is prepared by reducing with lithium aluminium hydride methyl 2-methoxy-hexadecanoate which is prepared by methylating 2-hydroxyhexadecanoic acid. 2 - Hydroxy - hexadecanoic acid is prepared by hydrolysing 2-bromohexadecanoic acid. 2 - Ethoxy - hexadecanol - 1 is prepared by reducing ethyl - 2 - ethoxy - hexadecanoate which is prepared from ethyl 2-bromohexadecanoate and sodium ethoxide. Pharmaceutical compositions comprising as active ingredient a compound of Formula (I) together with a pharmaceutically acceptable carrier are administered orally or parenterally and have anti-biotic and anti-carcinogenic activity.
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