water soluble material with immuno stimulating properties, method of preparation and partly preparations obtained in application.

摘要

An immunostimulant substance, denoted 34129 RP, is obtained from delipidated cells of Streptomyces stimulosus DS 25556 (NRRL 5776), by a process which comprises subjecting these delipidated cells to repeated autolysis, thereafter fractionating the water-soluble portion of the autolysis product by ultrafiltration to obtain substances whose molecular weight is 2000 to 20,000, and isolating the water- soluble substance 34129RP thus obtained after lyophilization of the solution. The immunostimulant substance is water-soluble, and can be administered by numerous routes to humans and to animals, preferably in the form of conventional pharmaceutical formulations. The immunostimulant, which has an elementary analysis; C40.4-41.1%; H 6.7-6.9%, N 8.0-10.6%, comprises alamine (5 to 7%), glutamic acid (7 to 10%), glycine (2.5 to 4%), alpha , alpha , diaminopimelic acid (5 to 8%), N-acetyl- glucosamine (5 to 10%) and muramic acid (5 to 10%).